Mauro Picardo of Istituto Dermatologico San Gallicano - Istituti Fisioterapici Ospitalieri, Rome. Read publications, and contact Mauro Picardo on. Mauro Picardo is an Editor at PeerJ. Bio: Director of the Cutaneous Physiopathology Laboratory and Metabolomic Center San Gallicano Dermatological Institute. Antioxidant activity, lipid peroxidation and skin diseases. What's new. S Briganti, M Picardo. Journal of the European Academy of Dermatology and Venereology.
Anti-HPV vaccination in Italy: Stress-activated cellular senescence as a mechanism of melanocytes degeneration in vitiligo more. Apr 1, Publication Name: Association of p53 Arg72Pro polymorphism and? Recently, abnormal accumulation of Polymorphism , Clinical Sciences , and Mycosis Fungoides.
Tacalcitol and narrow-band phototherapy in patients with vitiligo more. Vitiligo is a skin disease characterized by loss of normal pigmentation in the skin. Several treatments exist but none is really effective. Recently, perturbations of calcium homeostasis in vitiliginous epidermis have been described Recently, perturbations of calcium homeostasis in vitiliginous epidermis have been described.
Based on these findings, the aim of this prospective, randomized, open-label study was to compare the effectiveness of narrow-band ultraviolet B NB-UVB phototherapy alone and the combination of NB-UVB and topical application of the vitamin D 3 analogue tacalcitol in the treatment of vitiligo.
In total, 32 subjects with generalized vitiligo and symmetrical lesions were enrolled in the study. Subjects were instructed to apply tacalcitol ointment daily to the lesion on the side randomly selected to receive combination therapy. Application of tacalcitol ointment in combination with twice-weekly NB-UVB phototherapy is an effective alternative treatment for patients with generalized vitiligo.
Jan 9, Publication Name: GSK3p inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes more. Cellular Signalling and Tyrosinase. A rationale for glutathione therapy: Is antioxidant therapy a promising strategy to improve human reproduction?
Treatment and Human reproduction. Jul 7, Publication Name: The Journal of Immunology. Immunology of the Gut and The. Novel health economic evaluation of a vaccination strategy to prevent HPV-related diseases: Human papillomavirus HPV plays a role in the development of benign and malign neoplasms in both sexes. The Italian recommendations for HPV vaccines consider only females. The BEST II study Bayesian modelling to assess the Effectiveness of a vaccination Strategy to prevent HPV-related diseases evaluates 1 the cost-effectiveness of immunization strategies targeting universal vaccination compared with cervical cancer screening and female-only vaccination and 2 the economic impact of immunization on various HPV-induced diseases.
The objective of this study was to evaluate whether female-only vaccination or universal vaccination is the most cost-effective intervention against HPV. We present a dynamic Bayesian Markov model to investigate transmission dynamics in cohorts of females and males in a follow-up period of 55 years.
We assumed that quadrivalent vaccination against HPV 16, 18, 6, and 11 is available for year-old individuals. The sexual mixing is modeled on the basis of age-, sex-, and sexual behavioral-specific matrices to obtain the dynamic force of infection. Probabilistic sensitivity analysis shows a relatively large amount of parameter uncertainty, which interestingly has, however, no substantial impact on the decision-making process.
The intervention being assessed seems to be associated with an attractive cost-effectiveness profile. Universal HPV vaccination is found to be a cost-effective choice when compared with either cervical cancer screening or female-only vaccination within the Italian context. A kindred with familial progressive hyperpigmentation-like disorder: Two patients with a generalized, progressive dyschromatosis disorder are described and investigated as a model to study the role of fibroblast-derived mediators on skin pigmentation.
The patients father and daughter had had a widespread These features resembled those of familial progressive hyperpigmentation FPH. Histology revealed a normal epidermis with pronounced keratinocyte hyperpigmentation and the presence of dermal melanophages. Ultrastructural analysis showed basal and suprabasal keratinocytes enriched in melanosome complexes.
Immunohistochemical staining displayed an increased expression of hepatocyte growth factor HGF , stem cell factor SCF and keratinocyte growth factor KGF in fibroblast-like cells of the upper dermis in hyperpigm European journal of dermatology: The endocytic pathway followed by the keratinocyte growth factor receptor more.
It binds to and activates a receptor tyrosine kinase, the KGF receptor KGFR , which is a splicing variant of the fibroblast growth factor receptor 2. The endocytic pathway followed by KGF and its receptor was analyzed here using immunofluorescence and confocal microscopy. After 10 min of internalization at 37 degrees C, both KGF and its receptor were localized in early endosomes, and after min of endocytosis ligand and receptor were seen to reach perinuclear late endosomes and not the recycling endosomal compartment.
Parallel western blot analysis revealed that KGFRs were tyrosine phosphorylated both at early and late steps of internalization, suggesting that KGF and KGFR remain associated in active complexes through the endocytic pathway.
Pulse-chase experiments showed that the internalized KGFRs underwent degradation detectable at 1 h of endocyt Histochemistry and cell biology. Translational and Translational Oncology. Acne and smoking more. Scavenger systems in melanocytes from vitiligo subjects more. Moreover, the alterations in the cell membrane lipids, such as the decrease in the polyunsaturated fatty acid content of phospholipids and the increase in cholesterol levels, which are typical features of cell aging, were prevented.
Latent tuberculosis infection in patients with chronic plaque psoriasis who are candidates for biological therapy more. Screening for latent tuberculosis infection LTBI is mandatory in patients with psoriasis prior to biological therapy. To investigate the prevalence of LTBI in patients with psoriasis who are candidates for biological therapy. LTBI was diagnosed in 8. Prophylaxis with isoniazid is effective in preventing tuberculosis reactivation in patients with LTBI receiving biological therapy.
British Journal of Dermatology. Endocytic pathways and biological effects induced by UVB-dependent or ligand-dependent activation of the keratinocyte growth factor receptor more.
UVB exposure of epidermal cells is known to trigger early and late molecular pathways dependent on receptor tyrosine kinases and reactive oxygen species ROS. We have recently reported that UVB irradiation induces tyrosine We have recently reported that UVB irradiation induces tyrosine phosphorylation, kinase activation, and internalization of the receptor for the keratinocyte growth factor KGFR , a paracrine mediator of epithelial growth, differentiation, and survival. Immunogold electron microscopy and confocal analysis revealed that the UVB-induced endocytosis of KGFR occurs through clathrin-coated pits and that the internalized receptors are sorted to the degradative route and reach the lysosomal compartment with a timing similar to that induced by their ligand KGF.
Treatment with the anti-oxidant N-acetylcysteine inhibited KGFR endocytosis, suggesting that the receptor internalization is mediated by the intracellular production of ROS.
The ligand-independent KGFR endocytic pathway induced by UVB requires receptor kinase activity and tyrosine phosphorylation and involves transient receptor ubiquitination. In addition, receptor internalization leads to protection from apoptosis caused by UVB exposure.
A Possible Model of Degenerative Diseases more. We demonstrated a direct correlation between melanogenic and catalase activities on in vitro and ex vivo models. Here, we investigated whether the stimulation of Melanocortin-1 Receptor MC1R could influence catalase expression, activity Would you like to tell us about a lower price?
If you are a seller for this product, would you like to suggest updates through seller support? As Director of the Integrated Center of Metabolomic Research CIRM at the San Gallicano Institute, he coordinates lipidomic studies on acne and related disorders seborrheic dermatitis, rosacea in sebum and blood samples. The team is specialised in vitiligo and in particular in the study of the biological and molecular mechanisms involved in pigmentation with the aim of finding new preventative and therapeutic treatments.
Professor Picardo has organized several national and international conferences such as the Vitiligo International Symposium held in Rome in Dec and is member of the Editorial Board of many dermatological and biochemical journals including Pigment Cell and Melanoma Research and Experimental Dermatology.
He is author of more than publications in peer-reviewed journals and more than 30 chapters in different books, most of which are dedicated to pigmentation, focusing on both the biological and clinical approaches. Has authored more than articles in peer-reviewed journals and more than 40 chapters in multiauthored books. His major topics of interest are paediatric dermatology, genodermatoses, atopic dermatitis, pigment cell disorders and the ex-vivo study of the epidermal melanin unit physiology and pathophysiology.
He has received the Certificate of appreciation of the International League of Dermatological Societies ILDS in for several achievements made during his career and the American Skin Association award for his work on pigment cell disorders in Read more Read less. Credit offered by NewDay Ltd, over 18s only, subject to status. See all free Kindle reading apps. Start reading Vitiligo on your Kindle in under a minute. Don't have a Kindle? Be the first to review this item Amazon Bestsellers Rank: From the Back Cover Since the first edition of this book was published, new knowledge has been gained on Vitiligo.
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San Gallicano Hospital. Rome, Italy. View All. mini profile avatar Mauro Picardo. Overview · Bio · Network68 · Publications · Editorial Contributions1 · Impact. Vitiligo has been, until recently, a rather neglected area in dermatology and medicine. Patients complain about this situation, which has offered avenues to. View Mauro Picardo's profile on Publons with reviews.